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10/11(목)16시연사:안성수교수(가천대학교)
작성자 관리자조회수 59날짜 2018.10.05
일시: 10월 11일(목) 4:00PM

장소 : 벤처관 711호

연사: 안성수교수(가천대학교)

제목: Alzheimer's disease: Genetic and blood biomarkers for the diagnosis & therapy.

내용 : Many novel genetic variants were identified from patients with Alzheimer’s disease
(AD), especially patients under 65 years old, called early onset AD, in collaboration with
many institutes and hospitals. The next generation sequencing were employed in performing
the whole exome sequencings (WES). Autosomal dominant variants in 3 genes, amyloid
precursor protein, presenilin 1, and presenilin 2, from the patients could be identified easily,
accounting for only 1 % or less of all AD cases. Due to large amounts of data of other
genes from WES, we are in depth with overwhelming data. Hence, the gene panel of 100
potential genes in neurodegenerative diseases were selected for the further analyses.
Next, we developed Multimer Detection System for AD (MDS-OAβ), a new enzymelinked
immunosorbent assay for measuring Aβ oligomers (OAβ) selectively. MDS-OAβ was
used to detect OAβ in the plasma of patients with AD and healthy control individuals. The
plasma levels of OAβ by MDS were higher in patients with AD than in normal control
individuals, and they correlated well with conventional AD biomarkers. Plasma levels of
OAβ could be assessed using MDS, which might be a simple, noninvasive, and accessible
assay for evaluating brain amyloid deposition related to AD pathology.
In conclusion, MDS-OAβ is being used to screen therapeutic agents for the potential
leads in AD.
Keywords: Alzheimer's disease, Multimer Detection System, diagnosis, therapeutic agents
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