연구 및 대학원

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대학원 세미나

11/14(목)16시 연사:조윤성 (㈜클리노믹스 게놈연구소 연구소장)
작성자 관리자조회수 55날짜 2019.11.08
일시: 11월 14일(목) 4:00PM

장소 : 벤처관 711호

강사: 조윤성 (㈜클리노믹스 게놈연구소 연구소장)

제목: De novo sequencing and assembly strategies for the draft genome

내용: Reference genome is the most fundamental resource for biological sciences. Recent advances in genome sequencing and bioinformatics technologies have enabled humans to generate and investigate the genomes of various species. So far, nearly 500 species genomes have been assembled and annotated for the eukaryotic taxa. Importantly, eukaryotic genomes vary dramatically in terms of genome complexity, making it a challenge to revolve them with next-generation sequencing short reads alone. For example, marine animal and plant genomes usually have a high level of heterozygosity, repeat content, and genome-wide duplication, resulting de novo assemblies of them are highly fragmented. To overcome these challenges, researchers have adopted long-read sequencing (Oxford Nanopore and PacBio) technologies, as well as long-range scaffolding and whole genome mapping methods. We have successfully constructed several mammalian and marine reference genomes, such as Korean, tiger, minke whale, leopard, and raptors, using various genome technologies and bioinformatics analyses. Additionally, our extensive comparative evolutionary analysis revealed that they exhibited distinct genomic features that are associated with their physiological and morphological changes needed for their lifestyle and environmental adaptation.
이전 11/21(목)16시 연사:김희남 (고려대학교 바이오시스템의과학과 교수)
다음 11/07(목)16시 연사:정원일 (정보통계학 교수)