연구 및 대학원

연구 및 대학원

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대학원 세미나

11/07(목)16시 연사:정원일 (정보통계학 교수)
작성자 관리자조회수 54날짜 2019.11.04
일시: 11월 7일(목) 4:00PM

장소 : 벤처관 711호

강사: 정원일 (숭실대학교 정보통계학 교수)

제목: Polygenic Prediction in Biobank-Scale Cohorts and Statistical Analysis for Omics Data

내용: First, I will introduce cross-trait penalized regression (CTPR), a powerful and practical approach for multi-trait polygenic risk prediction in Biobank-scale cohorts. Specifically, I will talk about a novel cross-trait penalty function with Lasso and MCP to incorporate the shared genetic effects across multiple traits for large-sample GWAS data. Our novel implementation of a parallel computing algorithm makes it feasible to apply our method to biobank-scale GWAS data. Second, I will present statistical analysis procedure for large-sample genomics data to identify shared genetic architecture and related tissues for asthma-allergic disease, asthma-BMI and resting heart rate-T2D using fine-mapping, co-localization analysis, Mendelian randomization and TWAS. And I will briefly explain how to analyze methylomics data to predict cell type proportions for Asthma and airway inflammation and metabolomics data to detect metabolites associated with AMD.
이전 11/14(목)16시 연사:조윤성 (㈜클리노믹스 게놈연구소 연구소장)
다음 10/31(목)16시 연사:임동빈