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11/29(목)16시 연사:이혜자 박사(질병관리본부 내분비대사질환과)
작성자 관리자조회수 62날짜 2018.11.22
일시: 11월 29일(목) 4:00PM

장소 : 벤처관 711호

연사:연사:이혜자 박사(질병관리본부 내분비대사질환과)

제목: 비만성 인슐린저항증과 관련된 혈액 대사체 연구

내용 : Childhood obesity is strongly related to future insulin resistance and metabolic syndrome. Identifying early biomarkers of obesity-related diseases based on metabolic profiling is useful to control future metabolic disorders. Plasma metabolites were analysed from the Korean Child Obesity Cohort Study (KoCAS) using the AbsoluteIDQ™ p180 Kit. Baseline BCAAs were significantly positively correlated with both homeostasis model assessment for insulin resistance (HOMA-IR) and continuous metabolic risk score at the 2-year follow-up. Also, BCAAs were positively associated with circulating irisin, a novel exercise-induced myokine, which has been suggested to regulate energy metabolism (p<4×10-4 for Bonferroni correction). However, Functional interactions of metabolites with gene/proteins using biological pathway with insulin resistance were not identified biological significance and regulatory effects of asymmetric dimethylarginine (ADMA). However, ADMA showed a higher association with adolescent obesity (P < 0.001) and adult diabetes (P = 0.007) and decreased after obesity intervention program. Functional studies in cellular and mouse models demonstrated that an accumulation of ADMA is associated with the regulation of obesity-induced insulin resistance in skeletal muscle. ADMA treatment inhibited dimethylarginine-dimethylaminohydrolase (DDAH) activity and mRNA expression in insulin resistance muscle cell. Moreover, the treatment led to decrease of phosphorylation of insulin receptor (IR), AKT, and GLUT4 but increase of protein-tyrosine phosphatase 1B (PTP1B). Accordingly, increased ADMA significantly inhibited glucose uptake in myotube cell. We suggest that accumulation of BCAA and ADMA is associated with modulation of insulin signaling and insulin resistance. They might expand the possibilities of new therapeutic target for functional and clinical implications in the control of energy and metabolic homeostasis in humans.
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